Contents


327 Editor’s Choice December 2011 A. GELUK


Call For Papers

329 For a special issue of Leprosy Review on Chemotherapy R. GELBER


Editorial

330 Future for laboratory based research for leprosy P. J. BRENNAN

334 New insights and tools to combat leprosy nerve damage T. H. M. OTTENHOFF

338 Do we need laboratory based research any longer? S. L. WALKER

340 Keep the faith – leprosy still needs new diagnostic tools and laboratory research H. M. DOCKRELL


Original Papers

344 The Role of Mycobacterium leprae Phenolic Glycolipid I (PGL-I) in Serodiagnosis and in the Pathogenesis of Leprosy J. S. SPENCER AND P. J. BRENNAN

358 Anti-PGL-I seroepidemiology in leprosy cases: household contacts and school children from a hyperendemic municipality of the Brazilian Amazon J. G. BARRETO, L. DE SOUZA GUIMARÃES, M. R. N. LEÃO, D. V .G. FERREIRA, R. A. DE ARAÚJO LIMA AND C. G. SALGADO

371 Serum cytokine profile in leprosy and its correlation with clinico-histopathological profile N. KAWATRA MADAN, K. AGARWAL AND R. CHANDER

383 Serological detection of leprosy employing Mycobacterium leprae derived serine-rich 45 kDa, ESAT-6, CFP-10 and PGL-I: a compilation of data from studies in Indian populations O. PARKASH

389 Comparison of three immunological tests for leprosy diagnosis and detection of subclinical infection J. LOBATO, M. P. COSTA, E´. DE MELO REIS, M. A. GONÇALVES, J. S. SPENCER, P. J. BRENNAN, L. R. GOULART AND I. M. B. GOULART

402 Postgenomic Mycobacterium leprae antigens for cellular and serological diagnosis of M. leprae exposure, infection and leprosy disease A. GELUK, M. S. DUTHIE AND J. S. SPENCER

422 Cytokine responses to Mycobacterium leprae unique proteins differentiate between Mycobacterium leprae infected and naïve armadillos M. PENA, A. GELUK, J. J. VAN DER PLOEG-VAN SCHIP, K. L. M. C. FRANKEN, R. SHARMA AND R. TRUMAN

432 Development of a Mouse Food Pad Model for Detection of Sub Clinical Leprosy R. LAHIRI, B. RANDHAWA, K. L. M. C. FRANKEN, M. S. DUTHIE, J. S. SPENCER, A. GELUK AND J. L. KRAHENBUHL

445 Immunogenicity of Mycobacterium leprae unique antigens in leprosy endemic populations in Asia and AfricaK. BOBOSHA, J. J. VAN DER PLOEG-VAN SCHIP, M. ZEWDIE, B. R. SAPKOTA, D. A. HAGGE, K. L. M. C. FRANKEN, W. INBIALE, A. ASEFFA, T. H. M. OTTENHOFF AND A. GELUK