Contents

1 Editor’s Choice March 2011 D.N.J. LOCKWOOD


Editorial

3 Reflections on the new WHO leprosy indicator: The rate of new cases with grade 2 disabilities per 100,000 population per year E. DECLERCQ


Original Papers

6 Trends in new leprosy case detection over 57 years (1952–2008) in Yuxi, Yunnan Province of Southwest ChinaY.-Y. LI, X.-A. LI, L. HE, D. WANG, W.-Y. CHEN, L. CHEN, J.-B. LU AND Y.-G. YAO

17 Adverse effects of Multi-drug therapy in leprosy, a two years’ experience (2006–2008) in tertiary health care centre in the tribal region of Chhattisgarh state (Bastar, Jagdalpur) H. SINGH, B. NEL, V. DEY, P. TIWARI AND N. DULHANI

25 In vitro and skin lesion cytokine profile in Brazilian patients with borderline tuberculoid and borderline lepromatous leprosy J. VENTURINI, C.T. SOARES, A.D.F.F. BELONE, J.A. BARRETO,S. URA, J.R.P. LAURIS AND F.R. VILANI-MORENO

36 Detection of Mutations in folp1, rpoB and gyrA genes of M. leprae by PCR- direct sequencing – A rapid tool for screening drug resistance in leprosy B. SEKAR, K. ARUNAGIRI, B.N. KUMAR, S. NARAYANAN, K. MENAKA AND P.K. OOMMEN

46 A randomised controlled trial assessing the effect of adding clarithromycin to Rifampicin, ofloxacin and minocycline in the treatment of single lesion paucibacillary leprosy in Agra District, IndiaA. GIRDHAR, A. KUMAR AND B.K. GIRDHAR

55 Social participation of people affected by leprosy after discontinuation of multidrug therapy S.M.T. NARDI, V.D. PASCHOAL AND D.M.T. ZANETTA

65 Relapse study in smear positive multibacillary (MB) leprosy after 1 year WHO-multi-drug therapy (MDT) in Cebu, PhilippinesA. MAGHANOY, I. MALLARI, M. BALAGON AND P. SAUNDERSON

70 Qualitative Assessment of Medication Adherence at an Urban Leprosy Outpatient Clinic in Hyderabad, IndiaD. WEIAND, W.C. SMITH AND S. MUZAFFARULLAH


Case Report

74 Bilateral medial fingernail dystrophy as a presenting feature in a patient with leprosy P. BHUSHAN, A. AGGARWAL, R. YADAV AND V. BALIYAN


Letter to the Editor

78 Reasons for interrupting multidrug therapy against leprosy: the patients’ point of view O.A. CHICHAVA, L. ARIZA, A.R. OLIVEIRA, A.C. FERREIRA, L.F. MARQUES DA SILVA, J.C. BARBOSA, A.N. RAMOS JR AND J. HEUKELBACH


Workshop Report

80 Report on the Sixth Meeting of the IDEAL (Initiative for Diagnostic and Epidemiological Assays for Leprosy) Consortium held in Beijing, China on 23–25 August 2010 H.M. DOCKRELL, A. GELUK, P. BRENNAN, P.R. SAUNDERSON, L. OSKAM, D.N. LOCKWOOD, W. XIAOMAN AND J.H. RICHARDUS


News and Notes

86 Leprosy: Science working towards dignity

Working to overcome the global impact of neglected tropical diseases


Editorial

87 Leprosy statistics 2009: some thoughts E. DECLERCQ